Articles
Research articles:
- Single-cell multiomics reveals the interplay of clonal evolution and cellular plasticity in hepatoblastoma. Roehrig A, Hirsch TZ, Pire A, Morcrette G, Gupta B, Marcaillou C, Imbeaud S, Chardot C, Gonzales E, Jacquemin E, Sekiguchi M, Takita J, Nagae G, Hiyama E, Guérin F, Fabre M, Aerts I, Taque S, Laithier V, Branchereau S, Guettier C, Brugières L, Fresneau B, Zucman-Rossi J, Letouzé E. Nat Commun. 2024. PMID: 38589411, DOI: 10.1038/s41467-024-47280-x
- Mutational signature, cancer driver genes mutations and transcriptomic subgroups predict hepatoblastoma survival. Pire A, Hirsch TZ, Morcrette G, Imbeaud S, Gupta B, Pilet J, Cornet M, Fabre M, Guettier C, Branchereau S, Brugières L, Guerin F, Laithier V, Coze C, Nagae G, Hiyama E, Laurent-Puig P, Rebouissou S, Sarnacki S, Chardot C, Capito C, Faure-Conter C, Aerts I, Taque S, Fresneau B, Zucman-Rossi J. Eur J Cancer. 2024. PMID: 38330765. DOI: 10.1016/j.ejca.2024.113583
- Preneoplastic liver colonization by 11p15.5 altered mosaic cells in young children with hepatoblastoma. Pilet J, Hirsch TZ, Gupta B, Roehrig A, Morcrette G, Pire A, Letouzé E, Fresneau B, Taque S, Brugières L, Branchereau S, Chardot C, Aerts I, Sarnacki S, Fabre M, Guettier C, Rebouissou S, Zucman-Rossi J. Nat Commun. 2023. PMID: 37932266. DOI: 10.1038/s41467-023-42418-9
- A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1. Gallage S, Ali A, Barragan Avila JE, Seymen N, Ramadori P, Joerke V, Zizmare L, Aicher D, Gopalsamy IK, Fong W, Kosla J, Focaccia E, Li X, Yousuf S, Sijmonsma T, Rahbari M, Kommoss KS, Billeter A, Prokosch S, Rothermel U, Mueller F, Hetzer J, Heide D, Schinkel B, Machauer T, Pichler B, Malek NP, Longerich T, Roth S, Rose AJ, Schwenck J, Trautwein C, Karimi MM, Heikenwalder M. Cell Metabolism 2024. PMID: 38718791. doi: 10.1016/j.cmet.2024.04.015
- HBV-related HCC development in mice is STAT3 dependent and indicates an oncogenic effect of HBx. Ringelhan M, Schuehle S, van de Klundert M, Kotsiliti E, Plissonnier M-L, Faure-Dupuy S, Riedl T, Lange S, Wisskirchen K, Thiele F, Cheng C-C, Yuan D, Leone V, Schmidt R, Hünergard J, Geisler F, Unger K, Algül H, Schmid RM, Rad R, Heikenwalder M. JHEP Reports 2024. PMID: 39290403. doi: 10.1016/j.jhepr.2024.101128
- Oncogenic role of PMEPA1 and its association with immune exhaustion and TGF-β activation in HCC. Piqué-Gili M, Andreu-Oller C, Mesropian A, Esteban-Fabró R, Bárcena-Varela M, Ruiz de Galarreta M, Montironi C, Martinez-Quetglas I, Cappuyns S, Peix J, Keraite I, Gris-Oliver A, Fernández-Martínez E, Mauro E, Torres-Martin M, Abril-Fornaguera J, Lindblad KE, Lambrechts D, Dekervel J, Thung S, Sia D, Lujambio A, Pinyol R, Llovet JM. JHEP Reports 2024. doi: 10.1016/j.jhepr.2024.101212.
- Single-cell profiling of intrahepatic immune cells reveals an expansion of tissue-resident cytotoxic CD4+ T lymphocyte subset associated with pathogenesis of alcoholic-associated liver diseases. Gao C, Wang S, Xie X, Ramadori P, Li X, Liu X, Ding X, Liang J, Xu B, Feng Y, Tan X, Wang H, Zhang Y, Zhang H, Zhang T, Mi P, Li S, Zhang C, Yuan D, Heikenwalder M, Zhang P. Cell Mol Gastroenterol Hepatol. 2024. PMID: 39349248. doi: 10.1016/j.jcmgh.2024.101411.
- Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome. Gallage S, Irvine EE, Barragan Avila JE, Reen V, Pedroni SMA, Duran I, Ranvir V, Khadayate S, Pombo J, Brookes S, Heide D, Dharmalingham G, Choudhury AI, Singh I, Herranz N, Vernia S, Heikenwalder M, Gil J, Withers DJ. Nat Aging 2024. PMID: 39210150. doi: 10.1038/s43587-024-00695-z.
Reviews and Guidelines:
- Adjuvant and neoadjuvant immunotherapies in hepatocellular carcinoma. Llovet JM, Pinyol R, Yarchoan M, Singal AG, Marron TU, Schwartz M, Pikarsky E, Kudo M, Finn RS. Nat Rev Clin Oncol. 2024. doi: 10.1038/s41571-024-00868-0. PMID: 38424197.
- Two decades of advances in clinical oncology — lessons learned and future directions. Banerjee S, Booth CM, Bruera E, Büchler MW, Drilon A, Fry TJ, Ghobrial IM, Gianni L, Jain RK, Kroemer G, Llovet JM, Long GV, Pantel K, Pritchard-Jones K, Scher HI, Tabernero J, Weichselbaum RR, Weller M, Wu Y-L. Nat Rev Clin Oncol. 2024. PMID: 39354161. doi: 10.1038/s41571-024-00945-4.